Neurocysticercosis with initial clinical presentation of acute cysticercal meningitis coexisting with anterior chamber intraocular cysticercosis: a case report from a rural institute in India

Acute cysticercal meningitis coexisting with intraocular cysticercosis is an extremely infrequent clinical presentation of neurocysticercosis. We report a 26 year old male, who presented with signs and symptoms of acute eosinophilic cysticercal meningitis with intraocular cysticercosis in the anterior chamber of left eye. Diagnosis was confirmed with demonstration of cerebrospinal fluid (CSF) eosinophilia, cysticercus specific IgG antibodies by CSF ELISA, sterile bacterial, mycobacterial and fungal CSF cultures, cystic lesions containing characteristic scolices consistent with neurocysticercosis on neuroimaging and histopathological demonstration of cysticercus cellulosae larva viscoexpressed from the eye. The importance of having high index of clinical suspicion highlighted along with need of examining cerebrospinal fluid with Wright-Giemsa stain so as not to miss cerebrospinal fluid eosinophilia and diagnosis of this extremely under-reported clinical entity, when there is concurrent presence of brain and other extracerebral lesions consistent with cysticercosis

Facial Expression Analysis under Partial Occlusion: A Survey

Automatic machine-based Facial Expression Analysis (FEA) has made substantial progress in the past few decades driven by its importance for applications in psychology, security, health, entertainment and human computer interaction. The vast majority of completed FEA studies are based on non-occluded faces collected in a controlled laboratory environment. Automatic expression recognition tolerant to partial occlusion remains less understood, particularly in real-world scenarios. In recent years, efforts investigating techniques to handle partial occlusion for FEA have seen an increase. The context is right for a comprehensive perspective of these developments and the state of the art from this perspective. This survey provides such a comprehensive review of recent advances in dataset creation, algorithm development, and investigations of the effects of occlusion critical for robust performance in FEA systems. It outlines existing challenges in overcoming partial occlusion and discusses possible opportunities in advancing the technology. To the best of our knowledge, it is the first FEA survey dedicated to occlusion and aimed at promoting better informed and benchmarked future work.Comment: Authors pre-print of the article accepted for publication in ACM Computing Surveys (accepted on 02-Nov-2017

Composite conchal loss from Bluetooth headset device: An interesting case report

It is a well-known fact that talking on the phone while driving increases the risk of an accident. Bluetooth headset provides simple and uncomplicated route to hands-free communication. While driving, the use of hands-free phone devices such as earpieces and Bluetooth headset is equally as dangerous as talking on a cell phone normally. Here, we are reporting a very unique case of a 25-year-old male who sustained severe ear injury (full-thickness conchal defect of the size of earpiece of Bluetooth headset device; a very unusual mechanism of injury) in a road traffic accident while wearing a Bluetooth headset device. Two-stage repair was done using a retroauricular flap for full-thickness conchal defect. The post-operative cosmetic outcome achieved by this technique was satisfactory

A study to know the serum total testosterone levels in type II diabetes mellitus male patients from North India

Background: Diabetes mellitus is major public health issue facing the world in present century and the prevalence of type 2 diabetes is increasing explosively.  There are various diabetes related complications, one of which is low testosterone levels in men. This study was designed to estimate the serum testosterone level in male patients of type 2 diabetes mellitus.Methods: The patients of type -2 diabetes mellitus were picked up from out-patient and in-patients section of the hospital at random.Results: Seventy male  patients with type 2 diabetes mellitus were enrolled during the study period. The mean age of study population was 56.36±10.26 years (range 36-70), while that of control group patients was found to be 39.80±7.92years. Family history of diabetes was present in 14 (22.2%) patients. The mean HbA1c in study group was 8.83±1.95 %, which was significantly higher as compared to control group with HbA1c 4.82±0.40 %. Among study group, lower serum total testosterone level was observed in 85.7 % cases and normal level in 14.3 % cases. Among control group, lower serum total testosterone level was observed in 6.7 % cases and normal level in 93.3 % cases.Conclusions: The present study highlighted that significant difference in serum total testosterone level has been observed between cases and control groups (X2 =55.7, P=0.0001)

Study of association between the serum lipid profile and age-related macular degeneration in a tertiary care centre of Central UP

Background: Age-related macular degeneration (ARMD) is the major challenge in the new millennium in the developing countries as the size of elderly population continues to rise due to betterment of medical facilities and increased life expectancy. Lipids are implicated in the pathogenesis of ARMD. The relationship between systemic lipids and ARMD has not been well characterized, especially in rural population. The objective was to investigate the relationship between serum lipids and ARMD in older adults.Methods: In this case-control study, 300 adults, aged ≥50 years, 150 each among cases and controls were included in the study. Mean lipids values between cases and controls were compared.Results: Mean age of cases was 62.45±8.472 years and mean age of controls was 61.89±8.51 years. Among 150 cases, 124 (82.66%) cases were of dry ARMD while 26 (17.33%) cases were Wet ARMD. Author found that 38 cases among total cases (25.33%) and 15 individuals (10%) among controls had altered lipid profile. All mean lipid values were higher among cases compare to controls (p>0.05), while the mean of VLDL, TG and TG/HDL were significantly raised showing positive association (p<0.05).Conclusions: Present study showed that high levels of serum lipid values especially VLDL, TG and TG/HDL positive association with an increased risk for development of ARMD, implying that strategies reducing serum lipid levels may be useful to prevent the development of the disease

In Vitro Assessment of Antioxidant Capacity, Potential to Induce Autophagy/Mitophagy, and Mitochondrial Turnover of Natural Compounds for Cytotoxicity Studies

The dynamic process of intracellular reduction-oxidation status (redox homeostasis) is influenced by various factors, with mitochondria being one of the most significant contributors. Mitochondria play a crucial role in the bioenergetic pathway, fulfilling the metabolic energy demands of cells. To maintain increased energy requirements, mitochondrial biogenesis and fusion are employed, while decreased energy demands or damaged mitochondria are addressed through fission and autophagic removal, known as mitophagy. Any disruption in these adaptive responses can compromise redox homeostasis and cellular function, and make cells more vulnerable to oxidative stress, resulting in oxidative DNA damage, inflammatory responses, and apoptotic/anti-apoptotic reactions. Such dysregulation contributes to the development of “free radical diseases” like metabolic disorders and cancer. Traditional medicines and herbs (possessing antioxidant and autophagic properties) have been utilized for centuries in the treatment of various diseases; however, it is only recently that researchers have begun to investigate their molecular, cellular, and tissue-level modes of action. Nevertheless, concerns about their cytotoxicity have also arisen. This manuscript focuses on the current technological advancements in assessing the properties of plant-based natural compounds. Both cell-free and cell-based methods are employed to evaluate the therapeutic potential of these compounds, allowing for their scientific evaluation and validation

A study to know the various causes of pleural effusion and role of pleural fluid adenosine deaminase enzyme in tuberculous pleural effusion

Background: India has the maximum burden of both non MDR tuberculosis (TB) and Multidrug-Resistant (MDR) TB, as per data reported in Global TB Report 2018 and tuberculosis is remains one of the most common cause of pleural effusions.Methods: This was a cross-sectional study conducted in Department of Respiratory Diseases and a total of 110 patients with pleural effusion were included in the study, which were enrolled for treatment from July 2018 to June 2019.Results: One hundred and ten patients with pleural effusion were enrolled during the study period. There were 65 males (59%) and 45 (40.9%) females.  The overall mean age for males and females were 44.4±18.84 years (35-87 years) and 38.28±17.66 years (35-87 years) respectively. Tuberculous Pleural Effusion group (TPE) seen in 82 patients. Right sided pleural effusion (69.5 %) were more common than left sided (30.4 %). In TPE group the mean pleural fluid ADA level were 86.41±38.08 IU/L (range: 14-195 IU/L). The Malignant Pleural Effusion (MPE) group included 21 patients. In MPE group the mean pleural fluid ADA level were 34.10±32.88 IU/L (range: 8-144 IU/L). The difference in pleural fluid ADA levels between TPE and MPE group was statistically highly significant.Conclusions: Tuberculous pleural effusion was the most common cause of pleural effusion in present study and observed in 74.5% cases